Describe SAR of Quinolones with structural examples.
[6 marks]Give chemistry and classification of Cephalosporins.
[5 marks]Discuss mode of action and synthesis of Chloramphenicol.
[5 marks]Write a note on SAR of Tetracyclines.
[6 marks]Give synthesis and uses of Sulfamethoxazole and Acyclovir.
[5 marks]Define combinatorial chemistry. Describe concept and applications of combinatorial chemistry.
[5 marks]Classify Anti-tubercular agents with suitable examples from each category. Give synthesis of Isoniazid.
[6 marks]Give classification of antifungal agents.
[5 marks]Discuss chemical degradation of Penicillins.
[5 marks]Answer the following.
[6 marks]Life cycle of Malarial parasite. (ii) Benzimidazoles as Anthelmintic agents.
[ marks]Write a note on Macrolide antibiotics.
[5 marks]Give mode of action, chemistry and therapeutic uses of Aminoglycosides.
[5 marks]Define the term QSAR. Explain in brief on physicochemical parameters used in QSAR.
[6 marks]Write a note on SAR of Sulfonamides.
[5 marks]What are Prodrugs? Discuss basic concepts of Prodrug design. Give two examples of Prodrugs with their structures. Q. 6 (a) Write a note on Antiviral agents.
[6 marks]Write down synthesis of Mebendazole and Chloroquine.
[5 marks]Give a brief note on Antiprotozoal agents.
[5 marks]Discuss SAR of Quinolines as Antimalarial agents.
[6 marks]Write a note on pharmacophore modeling in drug design.
[5 marks]Give structure and uses of following drugs.
[5 marks]Chlortetracycline (ii) Nitrofurantoin (iii) Ciprofloxacin (iv) Clindamycin (v) Dapsone
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