Discuss the SAR of tetracyclines by giving suitable examples.
[6 marks]What is XDR-TB? Write a short note on first-line anti TB agents.
[5 marks]Give structure, IUPAC name and synthesis of Miconazole and Tolnaftate.
[5 marks]Discuss the chemistry and SAR of Penicillins.
[6 marks]Write synthesis of Ciprofloxacin and Acyclovir.
[5 marks]Describe malarial life cycle involving drugs acting on different stages.
[5 marks]Classify ß-lactam antibiotics by giving at least one structure from each class. Explain mechanism of action of ß-lactam antibiotics.
[6 marks]Define Prodrugs. Write short note on application of prodrugs design.
[5 marks]Give synthesis of Diethylcarbamazine citrate and Mebendazole.
[5 marks]Write IUPAC name and synthesis of Chloroquine and Pamaquine.
[6 marks]What is combinatorial chemistry? Write in depth about different methodologies used for synthesis.
[5 marks]Give Structure Activity Relationship of Cephalosporins.
[5 marks]Explain in detail about chemistry of Aminoglycosides.
[6 marks]Discuss various physicochemical parameters used in QSAR.
[5 marks]Give structure, IUPAC name and synthesis of Isoniazid and PAS. Q. 6 (a) Give brief account on SAR and chemistry of macrolide antibiotics.
[6 marks]Write Structure, IUPAC name and synthesis of Sulphamethoxazole and Trimethoprim.
[5 marks]Discuss SAR of Fluoroquinolones.
[5 marks]Give classification of anti-HIV agents and write a brief note on NNRTIs.
[6 marks]Write a short note on anti-protozoal agents.
[5 marks]Give structure, IUPAC name and synthesis of Chloramphenicol.
[5 marks]