What is drug metabolism? Describe various sites of drug metabolism.
[6 marks]Describe various metabolic oxidation reactions by giving suitable drug examples.
[5 marks]Why phase II metabolism is also known as conjugation reaction? Discuss sulfate conjugation.
[5 marks]Define receptors. Enlist types of it. Write in detail about ion channel receptors.
[6 marks]Write in brief about various bonds formed during drug-receptor interactions.
[5 marks]Explain the theories of drug-receptor interactions.
[5 marks]Enlist the classes of CNS stimulants. Write a note on hallucinogens.
[6 marks]Discuss the structure-activity relationship of tricyclic antidepressants.
[5 marks]Write the synthesis, IUPAC name and uses of Imipramine.
[5 marks]Classify the NSAIDs with chemical structures.
[6 marks]Write the synthetic steps of Mefenamic acid and Diclofenac.
[5 marks]Write a note on Disease Modifying Anti-Rheumatoid Drugs.
[5 marks]What are hypnotics? Classify the sedative-hypnotics with chemical structures.
[6 marks]Write the medicinal chemistry of inhalational anesthetics.
[5 marks]Discuss the SAR of barbiturates. Q. 6 (a) Write the synthesis and uses of Carbamazepine and Lignocaine.
[6 marks]Classify the antiepileptics with chemical structures.
[5 marks]Explain the SAR of local anesthetics.
[5 marks]Write the SAR and few examples with structures of antipsychotic phenothiazines.
[6 marks]Write a note on drugs used in Alzheimer’s disease.
[5 marks]Write a note on antiparkinsonian drugs.
[5 marks]