State and explain drug metabolism. Enlist phase-Ireactions and explain oxidation reactions in detail.
[6 marks]Define and classify the anxiolytics with chemical structures.
[5 marks]Give a synthetic scheme for the synthesis of Mefenamic acid and Diclofenac.
[5 marks]Discuss the SAR of tricyclic antidepressants with appropriate structural examples.
[6 marks]Give synthesis of Thiopental sodium and Phenobarbitone.
[5 marks]Write brief note on factors affecting drug metabolism.
[5 marks]Define hypnotics? Classify the sedative-hypnotics with chemical structures.
[6 marks]Sate and explain in detail about microsomal oxidation catalyzed by CYP450 including CYP450 cycle.
[5 marks]Give brief account of anti-gout agents,
[5 marks]Define and Classify the NSAIDs with chemical structures.
[6 marks]Write synthetic pathway for the synthesis of the (i) Lignocain (ii) Phenytoin
[5 marks]What is Parkinsonism ? Write synthesis of L-Dopa
[5 marks]Discuss SAR of Benzodiazepines with appropriate structural examples.
[6 marks]Write synthesis of Phenobarbitone and Chlopromazine
[5 marks]Give brief note on factors influencing the drug-receptor interaction. Q. 6 (a) Draw structure of I) Amphetamine II) Fluoxetine III) Imipramine IV)Halothane V) Chlordiazepoxide VI) Thiopental sodium
[6 marks]Define and classify the antiepileptics with chemical structures.
[5 marks]Define and classify the DMARDs with appropriate chemical structures.
[5 marks]Enlist types of receptors. Discuss different theories of drug-receptor interaction in detail
[6 marks]Discuss in detail about SAR of barbiturates with appropriate structural examples.
[5 marks]Define and give brief note on drugs used in Alzheimer’s disease.
[5 marks]