Pharmaceutical Chemistry VIII (Medicinal Chemistry II) — Summer 2022

Explain N-dealkylation, O-dealkylation and oxidative deamination metabolic reaction with suitable example.

Define biotransformation and xenobiotics. What happens to drugs in phase I and phase II metabolism?

Discuss any two phase II metabolic reactions.

What is the advantage of selective COX-II inhibitors as NSAIDs? Write five examples with structure of nonselective COX inhibitors as NSAIDs.

Classify the anti-gout agents with chemical structures and mechanism of action.

Define and classify the DMARDs with chemical structures.

Write the synthesis and use of thiopental sodium and chlorpromazine.

Describe the SAR of aniline derivatives with local anaesthetic activity.

Write the mechanisms of action of general anaesthetics. Write any three examples with structure of intravenous general anaesthetics.

Write the synthesis of

any one antiepileptic from hydantoin class ii) any one antiepileptic from iminostilbene class.

Classify the anxiolytics with chemical structures.

Discuss the SAR of barbiturates as sedative-hypnotics.

Write the chemistry aspects of tricyclic antidepressants.

Enumerate the classes of CNS stimulants. Write in detail on psychomotor stimulants.

Define psychedelics. Write any four examples of them with structures. Q. 6 (a) Write a detailed note on G-protein coupled receptors.

Discuss macromolecular perturbation theory and activation-aggregation theory of drug-receptor interaction.

Explain hydrogen bonding and covalent bonding between drug and receptor by giving suitable example.

Discuss the factors affecting drug metabolism.

Discuss the chemistry aspects of antiparkinsonian drugs which affect dopamine level.

Write a note on drugs used in Alzheimer’s disease.