Pharmaceutical Chemistry VIII (Medicinal Chemistry II) — Summer 2021

Define Receptor. Enlist different theories of Drug-Receptor interactions. Explain any two in detail.

Write a detailed note on factors affecting drug-receptor interaction.

Enlist various forces involved in Drug-Receptor interaction. Explain any two forces in detail.

Define drug metabolism. What do you mean by phase-Ireactions? Enlist phase- Ireactions and explain oxidation reaction in detail.

Write a detailed note on factors affecting drug metabolism.

Explain microsomal oxidation catalyzed by CYP450 including CYP450 cycle.

Define and classify antipsychotic agents with at least three drug names and one structure of each category.

Define general anesthetics. Discuss stages of anesthesia in detail.

Give SAR on Tricyclic antidepressants.

Give synthesis and use of: (Any three)

. Phenytoin ii). Carbamazepine iii). Lignocaine iv). L-Dopa

Write a short note on anxiolytic agents.

Give SAR on Benzodiazepines.

Give SAR on benzoic acid and aniline derivatives with local anesthetic activity.

Define and classify antiparkinson agents with at least three drug names and one structure of each category.

Give your knowledge about Analeptics. Q. 6 (a) Define and classify antiepileptic agents with at least three drug names and one structure of each category.

Match the followings: (Drug-Heterocyclic ring-Category) A). Drug B). Heterocyclic ring C). Category 1). Allopurinol a). Phenothiazine i). NSAID 2). Chlorpromazine b). Furan ii). Tricyclic antidepressant 3). Imipramine c). Indole iii). Antiepileptic 4). Ethotoin d). Pyrazolopyrimidine iv). Memory Enhancer 5). Indomethacin e). Quinoline v). Antigout

. Hydantoin vi). Local anesthetic

. Dibenzoazepine vii). Antipsychotic

Write a note on cognition enhancers.

Write a detailed note on antigout agents.

Write synthesis and IUPAC name of: (Any two)

. Diclofenac ii). Ibuprofen iii). Aspirin

Write an informative note on DMARDS.