Pharmaceutical Chemistry VIII (Medicinal Chemistry II) — Winter 2023

Enlist theories of Dug-Receptor interactions. Describe any three in details.

Define Xenobiotics. Give importance of CYP-450 in drug metabolism

Write a detailed note on factors affecting drug-receptor interaction.

Discuss conjugation as mechanism of metabolism

Write a note on Phase Ireactions of drug metabolism

Write a detailed note on factors affecting drug metabolism

What is Parkinson’s disease? Write a note on ant Parkinson’s agents.

What is epilepsy ? Classify antiepileptics with examples. Give synthesis of Phenytoin

Write a note on Alzheimer disease and its treatment

Write a detailed note on antigout agents

Classify NSAIDs and give their mechanism of action.

Define and classify the DMARDs with chemical structures.

. Paracetamol ii) Lignocaine iii) Carbamazepine

Write the chemistry aspects of tricyclic antidepressants

Give SAR of benzodiazepines

Give an account of general and local anesthetics with suitable examples. Q. 6 (a) Define and classify sedative and hypnotics with at least three drug examples and one structure of each category.

Give structure of: (Any five)

. Amphetamine ii). Allopurinol iii). Phenytoin iv). L-dopa

. Naproxen vi). Imipramine

Give synthesis and use of: (Any two)

Write the SAR and few examples with structures of antipsychotic phenothiazines

Discuss the SAR of barbiturates.

Write a short note on Analeptics