Pharmaceutical Chemistry VIII (Medicinal Chemistry II) — Winter 2020

Define and classify general anesthetics with example. Explain Structure activity relationship of Benzodiazepines.

Explain Structure activity relationship and mode of action of Tricyclic antidepressants.

Give synthesis of L-Dopa and Amphetamine.

Explain different theory of drug-receptor interactions in detail.

Write a brief note on factors affecting drug- receptor interaction.

Define Xenobiotics. Give importance of CYP-450 in drug metabolism

What is a CNS stimulant? Explain classification of CNS stimulants with suitable example. Write a brief note on hallucinogenic agents.

What is Parkinson’s disease? Write a note on antiparkinson’s agents.

Give synthesis of Halothane and Lignocaine.

Define and classify local anesthetics. Explain the SAR of Barbiturates.

Write a brief note on factors affecting drug metabolism.

Give synthesis of Thiopental sodium and Phenobarbitone.

What is psychosis? Explain briefly about SAR for Phenothiazines.

Write a brief note on antigout agents.

Give synthesis of Fluoxetine and Imipramine. Q. 6 (a) Explain Various forces involved in drug-receptor interaction.

Explain briefly about SAR for Local anesthetic agents.

Give synthesis of Chlordiazepoxide and Phenytoin.

Write a brief note on Phase-Iand Phase-II metabolism in detail.

Write a brief note on Cognition enhancers.

Write synthesis of Mefenamic acid and Nimesulide.