Discuss the physicochemical factors affecting the GI absorption of drugs.
[6 marks]Explain barriers to drug distribution.
[5 marks]Describe Noyes-Whitney equation.
[5 marks]Discuss the clinical significance of the Protein binding of drugs.
[6 marks]Write note on physicochemical properties influencing tissue permeability of drugs.
[5 marks]Write short notes on BCS.
[5 marks]Discuss the importance of in vitro and in vivo correlation in the bioavailability studies.
[6 marks]Discuss the significance of non renal excretion of drugs.
[5 marks]Write short notes on Pharmaceutical equivalence.
[5 marks]Explain method of residuals to calculate absorption rate constant of a drug following one compartment kinetics.
[6 marks]Discuss pharmacokinetic variables in disease states.
[5 marks]Write short notes on Volume of distribution.
[5 marks]List out the various pharmacokinetic parameters and define.
[6 marks]Write concept of Loading dose and Maintenance dose.
[5 marks]Write short notes on Phase Ireactions. Q. 6 (a) What are the causes of Non linearity? How will you determine the non linearity?
[6 marks]Explain Michaelis Menten equation.
[5 marks]How Blood brain barrier influence pharmacokinetic pattern of drug?
[5 marks]Give the criteria for obtaining valid urinary excretion data.
[6 marks]Explain sigma minus method to calculate Kfor a drug given by IV bolus by e following open compartment kinetics.
[5 marks]Discuss the various factors affecting distribution of drugs.
[5 marks]