Define: Biopharmaceutics, Pharmacokinetics, Mean residence time, Non renal excretion, Therapeutic window, Biotransformation.
[6 marks]Enumerate the various factors influencing GI absorption of drug. Explain particle size and surface area of the drug.
[5 marks]Explain the dissolution apparatus type Iand type II as per USP
[5 marks]Enlist the various mechanism of drug transport. Explain Passive diffusion.
[6 marks]Discuss the kinetics of protein binding.
[5 marks]Differentiate plasma-protein drug binding and tissue-drug binding
[5 marks]Why glucuronidation is the common and most important phase II reaction? Explain it.
[6 marks]Enlist the non renal routes of drug excretion and explain mammary excretion.
[5 marks]Enlist the methods for enhancement of bioavailability. Differentiate Absolute bioavailability & Relative bioavailability
[5 marks]Define bioequivalence. Explain Latin crossover design in BE studies.
[6 marks]Discuss Wagner Nelson Method.
[5 marks]Write a note on volume of distribution.
[5 marks]Discuss plasma drug concentration-time profile curve in detail.
[6 marks]Explain the terms Clearance, Total body clearance, Hepatic clearance and Renal clearance
[5 marks]Describe two compartment open model for IV bolus administration in brief. Q. 6 (a) Describe the methods of residuals for one compartment kinetics.
[6 marks]Enumerate the various pharmacokinetic models and explain mammillary model.
[5 marks]Give difference between linear & non linear pharmacokinetics
[5 marks]Explain Michaelis Menten equation in detail.
[6 marks]Discuss in brief about loading dose and maintenance dose.
[5 marks]Write causes of non linearity.
[5 marks]