Define given terms 1) Biopharmaceutics 2) Absorption 3) Bioavailability 4) Total clearance 5) Bioequivalence 6) Volume of distribution.
[6 marks]Explain barriers to drug distribution.
[5 marks]Enlist the various mechanism of drug transport. Differentiate active and passive transport.
[5 marks]Explain physicochemical factor affecting on drug absorption through oral route.
[6 marks]Write a note on kinetics of protein drug binding.
[5 marks]Discuss non-renal routes of drug excretion.
[5 marks]Define metabolism and briefly explain phase Ireaction.
[6 marks]Discuss Latin square cross over design in detail.
[5 marks]Explain various methods used for enhancement of bioavailability of poorly soluble drug.
[5 marks]Give a brief note on USP I, II, and II apparatus used for dissolution with figure.
[6 marks]Describe the methods of residuals for one compartment kinetics.
[5 marks]Write a short note on IVIVC.
[5 marks]What are pharmacokinetic models? Explain compartment model with their application in detail.
[6 marks]Derive equation in determination of Ka using Wagner Nelson method.
[5 marks]Explain the concept of loading and maintenance dose. Q. 6 (a) Draw a well labeled diagram of plasma drug concentration versus time plot and explain all pharmacokinetic parameters.
[6 marks]Explain sigma minus method to calculate Ke for a drug given by IV bolus for one compartment kinetics.
[5 marks]Discuss Michaelis-Menten equation for nonlinear pharmacokinetic
[5 marks]What is nonlinear pharmacokinetics? Discuss the factor causing of nonlinearity in detail.
[6 marks]Discuss on two compartment open model for intravenous bolus administration.
[5 marks]Write a difference between plasma-protein drug binding and tissue-drug binding.
[5 marks]