Discuss the physicochemical factors affecting the GI absorption of drugs.
[6 marks]Explain briefly about different mechanism of drug absorption.
[5 marks]Define drug distribution. Write a short note on volume of distribution.
[5 marks]Define clearance and write about renal clearance in detail.
[6 marks]Write a short note on kinetics of protein-drug binding.
[5 marks]Discuss factors affecting renal excretion of drugs.
[5 marks]Differentiate absolute and relative bioavailability. Discuss the pharmacokinetic methods for the bioavailability measurement.
[6 marks]Write a note on IVIVC.
[5 marks]Differentiate between plasma-protein drug binding and tissue-drug binding.
[5 marks]What are pharmacokinetic models? What are applications of such models? Discuss any one pharmacokinetic model.
[6 marks]What do you mean by nonlinear pharmacokinetics? Discuss factors causing Nonlinearity.
[5 marks]Explain Michaelis-menton equation.
[5 marks]Discuss briefly the concept of loading dose and maintenance dose.
[6 marks]Write a brief note on two compartment open model.
[5 marks]Explain merits and demerits of non-compartmental pharmacokinetics. Q. 6 (a) Write a brief note on physiological models.
[6 marks]Write on methods to enhance dissolution rate of poorly soluble drugs.
[5 marks]Derive equation in determination of absorption rate constant (Ka) using Wegner Nelson Method.
[5 marks]List out the various pharmacokinetic parameters and define.
[6 marks]Describe Latin Square cross over design for bioequivalence study.
[5 marks]Explain physiological barriers to drug distribution in body.
[5 marks]