Discuss the objectives and factors affecting drug absorption through oral route.
[6 marks]What is apparent volume of distribution. Discuss the influence of protein binding on apparent volume of distribution.
[5 marks]Discuss Michaelis-Menten Equation.
[5 marks]Define following terms: Absolute bioavailability, Relative Bioavailability, Bioequivalence.
[6 marks]Write a short note on kinetics of protein-drug binding.
[5 marks]Briefly describe factors affecting distribution of drug.
[5 marks]Introduce the concept of IVIVC. Discuss BCS based biowaivers in IVIVC briefly.
[6 marks]Write a short note on non-renal excretion of drugs.
[5 marks]Define high soluble and high permeable as per BCS classification. Enumerate various methods for improvement of dissolution rates of poorly soluble drug.
[5 marks]Explain Latin crossover design in bioequivalence studies.
[6 marks]Explain briefly what is compartmental model. Explain Catenary and Mammillary compartment models in detail
[5 marks]Describe the method of residuals for determination of absorption rate constant.
[5 marks]Write a note on PBPK models.
[6 marks]Enumerate USP dissolution apparatus along with examples of relevant dosage forms evaluated in each dissolution apparatus.
[5 marks]Explain Wagner nelson method in detail. Q. 6 (a) Discuss briefly the concept of loading dose and maintenance dose.
[6 marks]Write a brief note on two compartment open model.
[5 marks]Write a note on factors affecting protein binding with suitable examples.
[5 marks]Explain the factors causing non linearity in pharmacokinetics in drugs.
[6 marks]Explain merits and demerits of non-compartmental pharmacokinetics.
[5 marks]Differentiate between plasma-protein drug binding and tissue-drug binding.
[5 marks]