Discuss the kinetics of protein binding.
[6 marks]Enlist various factors responsible for protein binding and explain any one in detail.
[5 marks]Explain binding of drug to blood components giving suitable examples
[5 marks]Comment on passive diffusion is one of the important mechanisms of drug absorption.
[6 marks]Enlist various factors influencing GI absorption of a drug from its dosage form and explain physicochemical factors affecting drug absorption in detail.
[5 marks]Discuss the absorption of drugs from non-oral extra vascular routes
[5 marks]Discuss various methods used for the measurement of bioavailability
[6 marks]What are the problems faced in formulation of BCS Class II drugs? Discuss suitable strategies to overcome them.
[5 marks]Define the following terms first pass metabolism, active diffusion, bioavailability and bioequivalence
[5 marks]Discuss USP dissolution apparatus with specific uses
[6 marks]Explain In-vitro - In-vivo correlations
[5 marks]Describe Latin Square cross over design for bioequivalence study
[5 marks]Write a note on renal excretion of drugs
[6 marks]Define biotransformation and discuss in brief phase Iand Phase II biotransformation
[5 marks]Explain the following terms Clearance, Total body clearance, Hepatic clearance and Renal clearance Q. 6 (a) Explain the method of residuals for the calculation of absorption rate constant on administration of drug by Extra vascular route.
[6 marks]Write Note on Non compartmental Analysis
[5 marks]Write a note on Wagner Nelson Method
[5 marks]What process of drug ADME are known to show non linearity? Explain giving suitable examples.
[6 marks]Explain Michaelis Menten equation for capacity limited process
[5 marks]What are pharmacokinetic models? Explain in detail compartment models
[5 marks]